Abstract
((S)-1-(1,3,5-trimethyl)benzylpyrrolidin-2-yl)diphenylmethanol (1d) was found to be an effective chiral ligand in the asymmetric transfer reaction of phenyl to aldehydes to give the corresponding adducts in excellent enantioselectivity (up to 98% ee) with very high yields (up to 99%).
Keywords: Tertiary amino alcohol, transfer reaction, phenylboronic acid, diethyl zinc, diarylmethanols.
Letters in Organic Chemistry
Title:Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands
Volume: 11 Issue: 5
Author(s): Yongmin Liu, Rongcheng Bo, Nan Wu, Yuehua Qiao, Yong Li, Hui Wu and Zhou Xu
Affiliation:
Keywords: Tertiary amino alcohol, transfer reaction, phenylboronic acid, diethyl zinc, diarylmethanols.
Abstract: ((S)-1-(1,3,5-trimethyl)benzylpyrrolidin-2-yl)diphenylmethanol (1d) was found to be an effective chiral ligand in the asymmetric transfer reaction of phenyl to aldehydes to give the corresponding adducts in excellent enantioselectivity (up to 98% ee) with very high yields (up to 99%).
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Cite this article as:
Liu Yongmin, Bo Rongcheng, Wu Nan, Qiao Yuehua, Li Yong, Wu Hui and Xu Zhou, Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands, Letters in Organic Chemistry 2014; 11 (5) . https://dx.doi.org/10.2174/1570178611666140124000908
DOI https://dx.doi.org/10.2174/1570178611666140124000908 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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