Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands
Yongmin Liu, Rongcheng Bo, Nan Wu, Yuehua Qiao, Yong Li, Hui Wu and Zhou Xu
Affiliation: Department of Chemistry, Xuzhou Medical College, Xuzhou 221004, P.R. China.
Keywords: Tertiary amino alcohol, transfer reaction, phenylboronic acid, diethyl zinc, diarylmethanols.
((S)-1-(1,3,5-trimethyl)benzylpyrrolidin-2-yl)diphenylmethanol (1d) was found to be an effective chiral ligand
in the asymmetric transfer reaction of phenyl to aldehydes to give the corresponding adducts in excellent enantioselectivity
(up to 98% ee) with very high yields (up to 99%).
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