Background: Marijuana is the most commonly used illicit substance in the United States and worldwide. Marijuana
use is a problem of increasing magnitude among adolescents. Use typically begins in adolescence and is associated
with a variety of adverse outcomes.
Method: This article will present an overview of trends in marijuana use, and will review the endocannabinoid system and
marijuana. It will discuss recent policy developments in US and their implications, especially for adolescents. Existing
treatments will be reviewed, including findings from a recent randomized double-blind trial of N-acetylcysteine, a compound
that reverses the dysregulation of the glutamate system that occurs in substance dependence.
Conclusions: The core treatment approaches include psychosocial interventions, sometimes in combination with each
other. While a reduction in days of use is often achieved with most of these approaches, abstinence is a much more elusive
goal. The evidence base for effective treatments remains inadequate especially with regard to adolescents, and there is an
urgent need for more research in this area. Promising new treatments include N-acetylcysteine in conjunction with contingency