The arm of this review was to help general pediatricians and primary care physicians in diagnosing and
managing cow’s milk protein allergy in exclusively breast-fed infants.
Allergic proctocolitis is a cause of rectal bleeding in exclusively breast-fed infants aged from 1 to 6 months.It is due to
cow’s milk protein transferred via breast milk. Diagnosis is based on clinical features and recovery after dietetic therapy.
Rectal bleeding generally resolves within 72-96 hours of cow’s milk protein maternal avoidance. Most infants tolerate
cow’s milk by their first birthday.
Keywords: Allergic proctocolitis, α-S1-casein, β-lactoglobulin, blood streaked stool, breast-fed infants, cow’s milk proteins,
non-IgE mediated immunologic reactions.
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