Soy- and Rice-Based Formula and Infant Allergic to Cow's Milk
Flora Tzifi, Vasilis Grammeniatis and Marios Papadopoulos
Affiliation: 3rd Department of Pediatrics, University of Athens, “Attikon Hospital”, Rimini Str 1, Haidari, P. C. 12462, Athens, Greece.
Keywords: Children, cow’s milk allergy, rice allergenicity, rice formulas, soy allergenicity, soy formulas.
Soy milk formula has limited medical indications for infants feeding, although in several parts of the world it
has been used as a source of nutrition in a large number of children. It used to be the main alternative feeding for infants
allergic to cow’s milk who did not breastfeed before the introduction of extensively hydrolyzed formulas. Although there
is a debate, the fact that some children are allergic to soy or some children with cow’s milk allergy can present with
concomitant soy allergy, restricted the use of soy formulas for treatment of infants allergic to cow’s milk. Other grainbased
formulas like the rice-based ones are promising in infants with cow’s milk allergy. Grain-based formulas could be
an alternative and cheaper way of nutrition for infants allergic to cow’s milk than extensively hydrolyzed formulas.
Further large scale longitudinal clinical studies are required to clarify the safety of soy and other grain-based formulas for
treatment of cow’s milk allergy.
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