Cardioprotective Effect of Resveratrol and Resveratroloside
Sergey E. Naumenko, Tatiana V. Latysheva, Michael A. Gilinsky, Artem D. Rogachev, Nina I. Komarova, Nariman F. Salakhutdinov and Genrikh A. Tolstikov
Affiliation: Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia.
Keywords: Cardiovascular disease, in vivo experiments, ischemia-reperfusion, myocardial infarction, myocardial ischemia,
natural stilbenes, Pinus sibirica, preconditioning, resveratrol, resveratroloside.
Cardioprotective effect of resveratrol and resveratroloside was determined in ischemia-reperfusion experiments
on rats. It was found that single intraperitoneal administration of any compound (10 mg/kg) followed by 30-min ischemia
and 120-min reperfusion resulted in statistically significant decrease of myocardial infarct area (55.0±4.0% for control
group; 40.7±4.4% for the group 1 received resveratrol; 41.6±4.8% for the group 2 received resveratroloside). The
cardioprotective effect of resveratroloside was detected for the first time.
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