Cardioprotective Effect of Resveratrol and Resveratroloside
Sergey E. Naumenko,
Tatiana V. Latysheva,
Michael A. Gilinsky,
Artem D. Rogachev,
Nina I. Komarova,
Nariman F. Salakhutdinov,
Genrikh A. Tolstikov.
Cardioprotective effect of resveratrol and resveratroloside was determined in ischemia-reperfusion experiments
on rats. It was found that single intraperitoneal administration of any compound (10 mg/kg) followed by 30-min ischemia
and 120-min reperfusion resulted in statistically significant decrease of myocardial infarct area (55.0±4.0% for control
group; 40.7±4.4% for the group 1 received resveratrol; 41.6±4.8% for the group 2 received resveratroloside). The
cardioprotective effect of resveratroloside was detected for the first time.
Keywords: Cardiovascular disease, in vivo experiments, ischemia-reperfusion, myocardial infarction, myocardial ischemia,
natural stilbenes, Pinus sibirica, preconditioning, resveratrol, resveratroloside.
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