MicroRNA-34a: Role in Cancer and Cardiovascular Disease

Author(s): Xi Chen , Jian-Ya Zhou , Jian-Ying Zhou .

Journal Name: Current Drug Targets

Volume 15 , Issue 4 , 2014

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Abstract:

Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.

Keywords: Cardiovascular diseases, microRNA-34a, molecular target therapy, neoplasms.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2014
Page: [361 - 373]
Pages: 13
DOI: 10.2174/1389450115666140120102935
Price: $58

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