Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational
levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases.
MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of
genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to
be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a
in cancer and cardiovascular disease, as well as the therapeutic potentials.
Keywords: Cardiovascular diseases, microRNA-34a, molecular target therapy, neoplasms.
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