Synthesis of Sulfonamides, Metal Complexes and the Study of In vitro Biological Activities

Title:Synthesis of Sulfonamides, Metal Complexes and the Study of In vitro Biological Activities

Volume: 9 Issue: 3

Author(s): Syed Shoaib Ahmad Shah, Muhammad Ashfaq, Tayyaba Najam, Muhammad Mehboob Ahmed, Salma Shaheen, Rukhsana Tabassum and Syeda Abida Ejaz

Affiliation:

Keywords: Sulfonamides, metal complexes, biological activity, anti-enzyme activity.

Abstract: A modified method for the synthesis of a series of substituted benzenesulfonamides from benzenesulfonylchloride and substituted amines (1:1) in aqueous media have been adopted at controlled pH (8-10). Transition metal complexes of synthesized ligands were also prepared by refluxing ligands and metal salts (2:1) for one hour. The synthesized compounds have been characterized by spectroscopic techniques (FTIR, ¹HNMR and mass spectrometry). Synthesized compounds were analyzed for their activity toward acetyl cholinesterase (AChE) inhibition, butyrylcholinesterase (BChE) inhibition, lipoxygenase (LOX) inhibition, antioxidant (DPPH) and antiurease. As regards biological activities of ligands, only N-(2-nitrophenyl) benzenesulfonamide (3) showed appreciated value of IC₅₀= 77.13± 00 mole against LOX while all metal complexes showed low activities. Cu complex (C-4) showed moderate activity against LOX while all the other metal complexes had no activity against any enzyme at all. Similarly Zn complexes (Z-2 to Z-6) showed little activity against AChE but the ligands showed no significant activity against any other. Metal complexes showed high capacity toward antiurease activity.

Cite this article as:

Shah Shoaib Ahmad Syed, Ashfaq Muhammad, Najam Tayyaba, Ahmed Mehboob Muhammad, Shaheen Salma, Tabassum Rukhsana and Ejaz Abida Syeda, Synthesis of Sulfonamides, Metal Complexes and the Study of In vitro Biological Activities, Current Bioactive Compounds 2013; 9 (3) . https://dx.doi.org/10.2174/157340720903140119152646