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Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 14
ISSUE: 6
DOI: 10.2174/1568026614666140118223412      Price:  $58









Recent Contributions of Elastin-Like Recombinamers to Biomedicine and Nanotechnology

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Author(s): F. Javier Arias, Mercedes Santos, Alicia Fernández-Colino, Guillermo Pinedo and Alessandra Girotti
Pages 819-836 (18)
Abstract:
The emergence of the new scientific field known as nanomedicine is being catalyzed by multiple improvements in nanoscience techniques and significant progress in materials science, especially as regards the testing of novel and sophisticated biomaterials. This conjuncture has furthered the development of promising instruments in terms of detection, bioanalysis, therapy, diagnostics and imaging. Some of the most innovative new biomaterials are protein-inspired biomimetic materials in which modern biotechnology and genetic-engineering techniques complement the huge amount of information afforded by natural protein evolution to create advanced and tailor-made multifunctional molecules. Amongst these protein-based biomaterials, Elastin-like Recombinamers (ELRs) have demonstrated their enormous potential in the fields of biomedicine and nanoscience in the last few years. This broad applicability derives from their unmatched properties, particularly their recombinant and tailor-made nature, the intrinsic characteristics derived from their elastin-based origin (mainly their mechanical properties and ability to self-assemble as a result of their stimuli-responsive behavior), their proven biocompatibility and biodegradability, as well as their versatility as regards incorporating advanced chemical or recombinant modifications into the original structure that open up an almost unlimited number of multifunctional possibilities in this developing field. This article provides an updated review of the recent challenges overcome by using these recombinant biomaterials in the fields of nano- and biomedicine, ranging from nanoscale applications in surface modifications and self-assembled nanostructures to drug delivery and regenerative medicine.
Keywords:
Elastin-like recombinamers, self-assembly, stimuli-responsive, tissue engineering, surface modification, drug delivery, nanotechnology.
Affiliation:
BIOFORGE Research Group, University of Valladolid, CIBER-BBN, Edificio I+D, Paseo de Belen 11, 47011, Valladolid, Spain.