Flow Chemistry to Control the Synthesis of Nano and Microparticles for Biomedical Applications

Author(s): Natalia Hassan, Felipe Oyarzun-Ampuero, Pablo Lara, Simón Guerrero, Valérie Cabuil, Ali Abou-Hassan, Marcelo J. Kogan.

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 5 , 2014

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Abstract:

In this article we review the flow chemistry methodologies for the controlled synthesis of different kind of nano and microparticles for biomedical applications. Injection mechanism has emerged as new alternative for the synthesis of nanoparticles due to this strategy allows achieving superior levels of control of self-assemblies, leading to higher-ordered structures and rapid chemical reactions. Self-assembly events are strongly dependent on factors such as the local concentration of reagents, the mixing rates, and the shear forces, which can be finely tuned, as an example, in a microfluidic device. Injection methods have also proved to be optimal to elaborate microsystems comprising polymer solutions. Concretely, extrusion based methods can provide controlled fluid transport, rapid chemical reactions, and cost-saving advantages over conventional reactors. We provide an update of synthesis of nano and microparticles such as core/shell, Janus, nanocrystals, liposomes, and biopolymeric microgels through flow chemistry, its potential bioapplications and future challenges in this field are discussed.

Keywords: Microfluidic, flow chemistry, nanoparticles, biopolymers, microgels, bioapplications.

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Article Details

VOLUME: 14
ISSUE: 5
Year: 2014
Page: [676 - 689]
Pages: 14
DOI: 10.2174/1568026614666140118213915
Price: $58

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