Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA


Assembled Core-Shell Nanostructures of Gold Nanoparticles with Biocompatible Polymers Toward Biology

Author(s): Dongxiang Li, Qianru Li, Xiongwen Hao, Yaojun Zhang, Zhupeng Zhang and Chunfang Li

Affiliation: State Key Laboratory Base of Eco-chemical Engineering, Lab of Colloids and Functional Nanostructures, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.


The present review focuses on core-shell nanostructures of spherical gold nanoparticles (Au NPs) and biocompatible polymers mainly from the view points of preparation approaches, nanocomposite properties and potential applications for biology. The preparation approaches are assorted into direct-reduction, covalent “graft-to”, “graft-from” approach, surface bonding and physical adsorption. Various biocompatible polymers are involved such as the thermosensitive polymers, pH-responsive polymers, antibiofouling polymers, conductive polymers and several natural polymers. The encapsulating and loading properties, cellular uptake and drug release control, as well as biorecognition, targeting and sensing potential are discussed in connection with biological systems. These polymeric gold nanocomposites will have a great potential in biotechnology and life science but also face enormous challenge in future applications.

Keywords: Nanostructures, gold nanoparticles, biopolymers, core-shell, biology.

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Article Details

Page: [595 - 616]
Pages: 22
DOI: 10.2174/1568026614666140118204000