The Role of NO-cGMP Signaling Pathway in Pancreatic Beta-cell Function
Insulin-secretion in pancreatic beta-cells is modulated by several second messengers and complex signaling
pathways. Nitric oxide has been usually associated with beta-cell apoptosis, as part of the physiopathology of Type-2 diabetes.
However there is increasing evidence that NO/cGMP signaling pathway is also involved in the secretory function
through the activation of some target proteins such as the modulation of glucokinase activity, ionic channels, protein
kinases, phosphodiesterases; and gene expression through the activation of transcription factors. These observations could
be useful to establish new therapeutic strategies to maintain beta-cell optimal response before the development of islet
dysfunction that leads to diabetes.
Keywords: Ca2+ channels, cGMP, insulin secretion, insulin transcription, Nitric oxide, pancreatic beta-cell, PKG, soluble
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