New Insulin-Mimetic and Hypoglycemic Hetero-Binuclear Zinc (II)/Oxovanadium(IV) Complex
Takayasu Moroki, Hiroyuki Yasui, Yusuke Adachi, Katsuhiko Yoshizawa, Airo Tsubura, Kazuhiko Ozutsumi, Misaki Katayama and Yutaka Yoshikawa
Over the last two decades, we have proposed several types of orally active insulin–mimetic mononuclear zinc(II) complexes based on several coordination environments. Herein, we demonstrate the hypoglycemic activity and potentially low testicular toxicity of a binuclear Zn2+/VO2+ complex of N,N′-bis(salicylidene)ethylenediamine ([(VOZn)fsaen]). The chemical structure of this complex was evaluated using an extended X-ray absorption fine structure (EXAFS) technique. The in vivo hypoglycemic effect of [(VOZn)fsaen] was evaluated using type-2-like diabetic model mice treated by daily oral administrations. The hetero-binuclear complex [(VOZn)fsaen] exhibited glucose-lowering effect without triggering morphological changes in the testes, despite the recognized potentially significant toxicity of oxovanadium(IV) (VO2+) complexes in the testes.
Antidiabetic effect, extended X-ray absorption fine structure, hetero-binuclear complex, testicular toxicity, zinc and
Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women’s University, 4-7-2 Minatojima-nakamachi, Chuo-ku, Kobe 650-0046, Japan.