A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent
Priscila N. de Azevedo, Leina S. Behenck, Josue S. Bello Forero, July A. Hernandez Munoz, Erika M. de Cavalho, Joel Jones Junior and e Flavia M. da Silva
Affiliation: Sintese Orgânica Ambiental - IQ/UFRJ, caixa postal: 68.584, CEP 21941-972 - Rio de Janeiro, RJ, Brasil.
We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a
catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound
synthesis with a methodology that is clean, economical and efficient.
Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.
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