Current Organic Synthesis

L.-N. He
Nankai University
P.R. China


A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent

Author(s): Priscila N. de Azevedo, Leina S. Behenck, Josue S. Bello Forero, July A. Hernandez Munoz, Erika M. de Cavalho, Joel Jones Junior and e Flavia M. da Silva

Affiliation: Sintese Orgânica Ambiental - IQ/UFRJ, caixa postal: 68.584, CEP 21941-972 - Rio de Janeiro, RJ, Brasil.

Graphical Abstract:


We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.

Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.

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Article Details

Page: [605 - 611]
Pages: 7
DOI: 10.2174/1570179411666140115225758
Price: $58