Abstract
We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.
Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.
Current Organic Synthesis
Title:A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent
Volume: 11 Issue: 4
Author(s): Priscila N. de Azevedo, Leina S. Behenck, Josue S. Bello Forero, July A. Hernandez Munoz, Erika M. de Cavalho, Joel Jones Junior and e Flavia M. da Silva
Affiliation:
Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.
Abstract: We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.
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Cite this article as:
Azevedo N. de Priscila, Behenck S. Leina, Forero S. Bello Josue, Munoz A. Hernandez July, Cavalho M. de Erika, Junior Jones Joel and Silva Flavia M. da e, A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent, Current Organic Synthesis 2014; 11 (4) . https://dx.doi.org/10.2174/1570179411666140115225758
DOI https://dx.doi.org/10.2174/1570179411666140115225758 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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