A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent
Priscila N. de Azevedo,
Leina S. Behenck,
Josue S. Bello Forero,
July A. Hernandez Munoz,
Erika M. de Cavalho,
Joel Jones Junior,
e Flavia M. da Silva.
We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a
catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound
synthesis with a methodology that is clean, economical and efficient.
Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.
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