An efficient and direct protocol is described for the preparation of 1-substituted 1H-1,2,3,4-tetrazoles by the reaction
of primary amines, triethyl orthoformate and sodium azide in the presence of catalytic amount of silica-supported
perchloric acid under solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages
such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.
Keywords: Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole, HClO4-SiO2, heterogeneous catalyst.
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