HClO4-SiO2 as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles

Author(s): Siavash Bahari, Akbar Rezaei.

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 1 , 2014

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An efficient and direct protocol is described for the preparation of 1-substituted 1H-1,2,3,4-tetrazoles by the reaction of primary amines, triethyl orthoformate and sodium azide in the presence of catalytic amount of silica-supported perchloric acid under solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.

Keywords: Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole, HClO4-SiO2, heterogeneous catalyst.

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Article Details

Year: 2014
Page: [55 - 58]
Pages: 4
DOI: 10.2174/157017861101140113161526

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PDF: 38