HClO₄-SiO₂ as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles

Title:HClO₄-SiO₂ as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles

Volume: 11 Issue: 1

Author(s): Siavash Bahari and Akbar Rezaei

Affiliation:

Keywords: Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole, HClO₄-SiO₂, heterogeneous catalyst.

Abstract: An efficient and direct protocol is described for the preparation of 1-substituted 1H-1,2,3,4-tetrazoles by the reaction of primary amines, triethyl orthoformate and sodium azide in the presence of catalytic amount of silica-supported perchloric acid under solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.

Cite this article as:

Bahari Siavash and Rezaei Akbar, HClO₄-SiO₂ as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles, Letters in Organic Chemistry 2014; 11 (1) . https://dx.doi.org/10.2174/157017861101140113161526