Racemic solketal (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol 1, was treated with carboxylic acids of varying
chain length or their vinyl esters in the presence of different lipases. The esterification reaction was carried out in
n-hexane or diisopropyl ether as a solvent. The yield of the solketal esters and their enantiopurity were satisfactory, as indicated
by gas chromatography using chiral column. Lipases from Rhizopus oryzae and Pseudomonas fluorescence gave
the best enantiomeric excess (ee) when the solketal was treated with vinyl butyrate in a solution of diisopropyl ether at
Keywords: Esterification, solketal, lipases, enantiopurity, biocatalysis.
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