Clarithromycin Induced Psoriasis in a 37-Year Old Man
Ahmed Zaiem, Amel Mebazaa, Ghozlane Lakhoua, Talel Badri, Rym Sahnoun, Sarrah Kastalli, Riadh Daghfous and Sihem El Aidli
Affiliation: National Center of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia.
Many drugs may induce psoriatic lesions or exacerbate preexisting psoriasis. We report an exceptional case of
psoriasis vulgaris probably induced by clarithromycin. A 37-year-old man was prescribed for pharyngitis clarithromycin
500mg twice a day. On the third day of treatment, he presented a non pruriginous erythemato-squamous eruption, of trunk
and limbs. Skin biopsy showed a typical aspect of psoriasis vulgaris. The drug was interrupted and the patient was treated
by topical corticoids with rapid improvement.
Keywords: Adverse drug reaction, clarithromycin, psoriasis.
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