Mucoadhesive Microspheres Containing Anti-Hypertensive Agent: Formulation and Characterization
Ankita Sunilbhai Patel, Pande Saikat and Patel Ronakkumar Pravinbhai
Affiliation: A.R. College of Pharmacy & G.H. Patel Institute of Pharmacy, Vallabh Vidyanagar, Anand, Gujarat, India.
The spherical microspheres consisting of Furosemide loaded sodium alginate and along with HPMC E50 or sodium
CMC as mucoadhesive polymers in different ratios were prepared using ionic gelation technique. Calcium chloride
was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. The prepared mucoadhesive microspheres
were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency,
mucoadhesion test and in vitro dissolution profile studies. Formulations were subjected to DSC study and SEM
analysis. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed non-Fickian diffusion
Keywords: Furosemide, Ionic gelation, Mucoadhesive polymers, Sodium alginate.
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