Tribromoisocyanuric Acid: A Green and Versatile Reagent
Leonardo S. de Almeida, Pierre M. Esteves and Marcio C. S. de Mattos
Affiliation: Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal do Rio de Janeiro, CP 68545, 21945-970, Rio de Janeiro, Brazil.
Keywords: Alkenes, arenes, dicarbonyl compounds, electrophilic reaction, green chemistry, Hunsdiecker reaction, oxidation,
The present review summarizes the synthetic application of tribromoisocyanuric acid [1,3,5-tribromo-1,3,5-
triazine-2,4,6-(1H,3H,5H)-trione] in organic synthesis and focuses on its green aspects. It is a safe, stable and easily prepared
solid. Electrophilic bromination reactions involving alkenes, arenes, dicarbonyl compounds and the bromodecarboxylation
of cinnamic acids (Hunsdiecker reaction), as well as benzylic bromination and some oxidations involving tribromoisocyanuric
acid are presented and discussed. In accordance with green chemistry principles, the use of tribromoisocyanuric
acid enables bromination without bromine or other harmful or dangerous reagents.
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