Personalized Drug Discovery: HCA Approach Optimized for Rare Diseases at Tel Aviv University
Leonardo J. Solmesky and Miguel Weil
Affiliation: Cell Screening Facility for Personalized Medicine, Laboratory for Neurodegenerative Diseases and Personalized Medicine, Department of Cell Research and Immunology, The Sagol School of Neurosciences, The George S. Wise Faculty for Life Sciences, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel.
Keywords: Drug repurposing, high content screening, nanomaterials characterization, personalized drug discovery,
personalized medicine, rare diseases.
The Cell screening facility for personalized medicine (CSFPM) at Tel Aviv University in
Israel is devoted to screening small molecules libraries for finding new drugs for rare diseases using
human cell based models. The main strategy of the facility is based on smartly reducing the size of
the compounds collection in similarity clusters and at the same time keeping high diversity of
pharmacophores. This strategy allows parallel screening of several patient derived - cells in a
personalized screening approach. The tested compounds are repositioned drugs derived from collections of phase III and
FDA approved small molecules. In addition, the facility carries screenings using other chemical libraries and toxicological
characterizations of nanomaterials.
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