Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
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The Role of HTS in Drug Discovery at the University of Michigan

Author(s): Martha J. Larsen, Scott D. Larsen, Andrew Fribley, Jolanta Grembecka, Kristoff Homan, Anna Mapp, Andrew Haak, Zaneta Nikolovska-Coleska, Jeanne A. Stuckey, Duxin Sun and David H. Sherman

Affiliation: Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Keywords: Drug discovery, high throughput screening, medicinal chemistry, pharmacokinetics, protein crystallography, structural biology.


High throughput screening (HTS) is an integral part of a highly collaborative approach to drug discovery at the University of Michigan. The HTS lab is one of four core centers that provide services to identify, produce, screen and follow-up on biomedical targets for faculty. Key features of this system are: protein cloning and purification, protein crystallography, small molecule and siRNA HTS, medicinal chemistry and pharmacokinetics. Therapeutic areas that have been targeted include anti-bacterial, metabolic, neurodegenerative, cardiovascular, anti-cancer and anti-viral. The centers work in a coordinated, interactive environment to affordably provide academic investigators with the technology, informatics and expertise necessary for successful drug discovery. This review provides an overview of these centers at the University of Michigan, along with case examples of successful collaborations with faculty.

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Article Details

Page: [210 - 230]
Pages: 21
DOI: 10.2174/1386207317666140109121546