The Role of HTS in Drug Discovery at the University of Michigan
Martha J. Larsen, Scott D. Larsen, Andrew Fribley, Jolanta Grembecka, Kristoff Homan, Anna Mapp, Andrew Haak, Zaneta Nikolovska-Coleska, Jeanne A. Stuckey, Duxin Sun and David H. Sherman
Affiliation: Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
High throughput screening (HTS) is an integral part of a highly collaborative approach
to drug discovery at the University of Michigan. The HTS lab is one of four core centers that
provide services to identify, produce, screen and follow-up on biomedical targets for faculty. Key
features of this system are: protein cloning and purification, protein crystallography, small
molecule and siRNA HTS, medicinal chemistry and pharmacokinetics. Therapeutic areas that have
been targeted include anti-bacterial, metabolic, neurodegenerative, cardiovascular, anti-cancer and
anti-viral. The centers work in a coordinated, interactive environment to affordably provide
academic investigators with the technology, informatics and expertise necessary for successful
drug discovery. This review provides an overview of these centers at the University of Michigan,
along with case examples of successful collaborations with faculty.
Keywords: Drug discovery, high throughput screening, medicinal chemistry, pharmacokinetics, protein crystallography,
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