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Current Bioinformatics
ISSN (Print): 1574-8936
ISSN (Online): 2212-392X
VOLUME: 9
ISSUE: 2
DOI: 10.2174/1574893608999140109120612      Price:  $58









A Review of the Computational Methods for Identifying the Over- Annotated Genes and Missing Genes in Microbial Genomes

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Author(s): Jia-Feng Yu, Zhen-Zhen Guo, Xiao Sun and Ji-Hua Wang
Pages 147-154 (8)
Abstract:
More and more studies indicate that the issue of protein-coding gene finding in microbial genomes is far from thoroughly solved and the annotation quality has been questioned continuously in the past several years. In this paper, we summarize the computational methods for identifying the over-annotated genes and missing genes, and provide perspective for prospective gene finding works.
Keywords:
Microbial genome, missing gene, over-annotated gene, protein-coding gene, re-annotation.
Affiliation:
Shandong Provincial Key Laboratory of Biophysics for Functional Macromolecules, Dezhou University, Dezhou 253023, China.