Current Bioinformatics

Alessandro Giuliani
Istituto Superiore di Sanitá (Italian NIH) Environment and Health Dept
Roma
Italy

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A Review of the Computational Methods for Identifying the Over- Annotated Genes and Missing Genes in Microbial Genomes

Author(s): Jia-Feng Yu, Zhen-Zhen Guo, Xiao Sun and Ji-Hua Wang

Affiliation: Shandong Provincial Key Laboratory of Biophysics for Functional Macromolecules, Dezhou University, Dezhou 253023, China.

Keywords: Microbial genome, missing gene, over-annotated gene, protein-coding gene, re-annotation.

Abstract:

More and more studies indicate that the issue of protein-coding gene finding in microbial genomes is far from thoroughly solved and the annotation quality has been questioned continuously in the past several years. In this paper, we summarize the computational methods for identifying the over-annotated genes and missing genes, and provide perspective for prospective gene finding works.

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Article Details

VOLUME: 9
ISSUE: 2
Page: [147 - 154]
Pages: 8
DOI: 10.2174/1574893608999140109120612