Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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A Review of the Computational Methods for Identifying the Over- Annotated Genes and Missing Genes in Microbial Genomes

Author(s): Jia-Feng Yu, Zhen-Zhen Guo, Xiao Sun and Ji-Hua Wang

Affiliation: Shandong Provincial Key Laboratory of Biophysics for Functional Macromolecules, Dezhou University, Dezhou 253023, China.

Abstract:

More and more studies indicate that the issue of protein-coding gene finding in microbial genomes is far from thoroughly solved and the annotation quality has been questioned continuously in the past several years. In this paper, we summarize the computational methods for identifying the over-annotated genes and missing genes, and provide perspective for prospective gene finding works.

Keywords: Microbial genome, missing gene, over-annotated gene, protein-coding gene, re-annotation.

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Article Details

VOLUME: 9
ISSUE: 2
Page: [147 - 154]
Pages: 8
DOI: 10.2174/1574893608999140109120612
Price: $58