Nature Bank and the Queensland Compound Library: Unique International Resources at the Eskitis Institute for Drug Discovery
Ngoc B. Pham,
Ronald J. Quinn.
The Eskitis Institute for Drug Discovery is home to two unique resources, Nature Bank and the
Queensland Compound Library (QCL), that differentiate it from many other academic institutes pursuing
chemical biology or early phase drug discovery. Nature Bank is a comprehensive collection of plants and
marine invertebrates that have been subjected to a process which aligns downstream extracts and fractions
with lead- and drug-like physicochemical properties. Considerable expertise in screening natural product
extracts/fractions was developed at Eskitis over the last two decades. Importantly, biodiscovery activities
have been conducted from the beginning in accordance with the UN Convention on Biological Diversity
(CBD) to ensure compliance with all international and national legislative requirements. The QCL is a
compound management and logistics facility that was established from public funds to augment previous
investments in high throughput and phenotypic screening in the region. A unique intellectual property (IP)
model has been developed in the case of the QCL to stimulate applied, basic and translational research in the chemical and life
sciences by industry, non-profit, and academic organizations.
Keywords: Compound management, drug discovery, Eskitis Institute, lead-like enhanced extracts, natural products, Nature
Bank, Queensland Compound Library.
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