Current Bioinformatics

Alessandro Giuliani
Istituto Superiore di Sanitá (Italian NIH) Environment and Health Dept


Identification of Marker Genes for Cancer Based on Microarrays Using a Computational Biology Approach

Author(s): Xiaosheng Wang

Affiliation: Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198-5805, USA.


Rapid advances in gene expression microarray technology have enabled to discover molecular markers used for cancer diagnosis, prognosis, and prediction. One computational challenge with using microarray data analysis to create cancer classifiers is how to effectively deal with microarray data which are composed of high-dimensional attributes (p) and low-dimensional instances (n). Gene selection and classifier construction are two key issues concerned with this topics. In this article, we reviewed major methods for computational identification of cancer marker genes based on microarray gene expression data. We concluded that simple methods should be preferred to complicated ones for their interpretability and applicability.

Keywords: Cancer, computational biology, marker genes, microarrays.

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Article Details

Page: [140 - 146]
Pages: 7
DOI: 10.2174/1574893608999140109115649