Metabolic Syndrome and Asthma
Jenny V. Garmendia, Dolores Moreno, Alexis H. Garcia and Juan B. De Sanctis
Affiliation: Instituto de Inmunologia, Facultad de Medicina, Universidad Central de Venezuela, Apartado 50109, Caracas 1050-A, Venezuela.
Metabolic syndrome (MetS) is a syndrome that involves at least three disorders dyslipidemia, insulin resistance,
obesity and/or hypertension. MetS has been associated with several chronic diseases in the adulthood; however, in
the recent years, the syndrome was redefined in children. Girls with early menarche and asthma, and children with MetS
and asthma that reach adulthood appear to have higher risk to develop severe or difficult to control asthma and a higher
probability to suffer cardiovascular diseases. It has been proposed that patients with MetS and endocrinological disorders
should be considered a different entity in which pharmacologic treatment should be adjusted according to the individual.
Recent patents on the field have addressed new issues on how endocrine control should be managed along with asthma
therapeutics. In the near future, new approaches should decrease the high morbidity and mortality associated to these
types of patients.
Keywords: Asthma, dyslipidemia, hypertension, immune response, insulin resistance, metabolic syndrome.
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