It is being recognized that the eukaryotic genome physically interacts with itselfviaa
complex network of long range chromatin interactions. While the insights to the underlying organizing
principles are being worked out, an interesting and rather provocative theme which is emerging is that
the genes can cross-talk to influence each others’ epigenetic states. If firmly established, this
observation would endow a novel perspective to the genetic and epigenetic basis of disease
development. In this letter, I discuss the present evidence and implications of long-range regulatory
cross-talk among genes.