Tritiated Opioid Receptor Ligands as Radiotracers

Author(s): Geza Toth , Jayapal Reddy Mallareddy .

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 42 , 2013

Abstract:

Tritiated opioid ligands are essential tools for the identification of opioid receptors. This review deals with the syntheses of tritiated opioid peptide derivatives, including enkephalins, dynorphins, dermorphins, deltorphins and endomorphins, and also discusses tritium-labeled nonpeptide opioids. It additionally focuses on the relevance of tritium-labeled opioid compounds as research tools for investigating opioid receptor pharmacology. Agonists and antagonists are used for the characterization of new opioid ligands by means of radioreceptor binding assays. Further topics covered in this review are the distribution of the endogenous peptides in the central nervous system and peripheral tissues, and degradation studies of opioids in brain membrane preparations and the blood.

Keywords: Radiotracers, tritium, opioid receptors, opiates, opioid peptides.

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Article Details

VOLUME: 19
ISSUE: 42
Year: 2013
Page: [7461 - 7472]
Pages: 12
DOI: 10.2174/138161281942140105170259
Price: $58

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