Current Angiogenesis

Guo-Chang Fan , PHD
Dept. of Pharmacology and Cell Biophysics
University of Cincinnati College of Medicine
Cincinnati
USA

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Quantization of Angiogenesis and Image Analysis

Author(s): Nikolaos Kavantzas, Vasileios Salpeas, Eleftheria Lakiotaki and Petros M. Pavlopoulos

Affiliation: First Department of Pathology, School of Medicine, University of Athens, 75 Mikras Asias str. GR-11527, Athens Greece

Keywords: Angiogenesis, image analysis.

Abstract:

Quantitative Pathology is engaged with the determination of morphological characteristics of tissues. One important field of measurement is the estimation of angiogenesis in malignant neoplasms. The parameters of angiogenesis that are determined include: microvascular density (MVD), total vascular area (TVA) and vessel’s major axis length, minor axis length, area, perimeter, compactness, shape factor and Feret diameter [1-3]. The statistical correlations of the above mentioned parameters with prognosis or clinicopathological characteristics result in conclusions about the malignant potential and aggressiveness of different malignant tumors. In the present review article, we identify basic morphometric parameters used to characterize angiogenesis and describe the method of quantization by the appropriate image analysis software.

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Article Details

VOLUME: 3
ISSUE: 4
Page: [245 - 249]
Pages: 5
DOI: 10.2174/2211552802666140104000902