Quantization of Angiogenesis and Image Analysis
Nikolaos Kavantzas, Vasileios Salpeas, Eleftheria Lakiotaki and Petros M. Pavlopoulos
Affiliation: First Department of Pathology, School of Medicine, University of Athens, 75 Mikras Asias str. GR-11527, Athens Greece
Quantitative Pathology is engaged with the determination of morphological
characteristics of tissues. One important field of measurement is the estimation
of angiogenesis in malignant neoplasms. The parameters of angiogenesis that
are determined include: microvascular density (MVD), total vascular area (TVA)
and vessel’s major axis length, minor axis length, area, perimeter, compactness,
shape factor and Feret diameter [1-3]. The statistical correlations of the above mentioned
parameters with prognosis or clinicopathological characteristics result in conclusions about
the malignant potential and aggressiveness of different malignant tumors. In the present review article,
we identify basic morphometric parameters used to characterize angiogenesis and describe the
method of quantization by the appropriate image analysis software.
Keywords: Angiogenesis, image analysis.
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