Latest Advances in Clinical and Pre-Clinical Cardiovascular MRI

Latest Advances in Clinical and Pre-Clinical Cardiovascular MRI

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Spinning to a Different Beat: Non-Proton Cardiac NMR and MRI

Pp. 107-129 (23)

Mangala Srinivas and I. Jolanda M. de Vries


Non-proton spectroscopy is a powerful tool that allows the assessment of specific and significant metabolites in cardiac tissue, such as key intermediates in energy metabolism. The technique uses spectroscopy, or less often imaging, of nuclei such as 31P, 19F and 23Na. Due to the non-invasive nature of MRS, the technique is also applicable in the clinic, where it is used to assess changes in cardiac metabolism, such as due to a heart infarct. This chapter reviews the main developments in non-proton cardiac MRS and MRI, both clinical and preclinical. Major issues and challenges are also summarized. Finally, the promise of exciting new developments, particularly hyper-polarization, is discussed.


19F, 23Na, 31P, ATP, chemical shift, clinical, energy metabolism, hyperpolarization, lanthanide, metabolism, MRS, spectroscopy, multimodal, NMR, noninvasive, non-proton, preclinical, quantification, sensitivity, spectrum.


Radboud University Medical Center, Department of Tumor Immunology, 278, Nijmegen Center for Molecular Life Sciences (NCMLS), Nijmegen, The Netherlands