Mini-Reviews in Medicinal Chemistry

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Development of Thiadiazole as an Antidiabetic Agent- A Review

Author(s): Prasanna A. Datar and Tejashree A. Deokule

Affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune-400041, India.

Keywords: Antidiabetic, cannabinoid-1 receptor, c-Jun N-terminal kinase, dipeptidyl peptidase-4, peroxisome proliferatoractivated receptor, protein tyrosine phosphatase, sodium-glucose linked transporter, thiadiazole.

Abstract:

This review provides a brief summary of thiadiazole ring containing compounds as antidiabetic agents. It covers the most active thiadiazole derivatives selected from reported literature of thiadiazole system as antidiabetic drug substance in the form of synthesis and structural activity relationship study reports. Some of the promising thiadiazole compounds interacting with targets such as sodium-glucose linked transporter, peroxisome proliferator-activated receptor, protein tyrosine phosphatase, c-Jun N-terminal kinase, dipeptidyl peptidase-4 and cannabinoid-1 receptor have been collected with their biological potency. The information provided in this review acts as important overview for medicinal chemist to develop a new chemical entity possessing antidiabetic activity.

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Article Details

VOLUME: 14
ISSUE: 2
Page: [136 - 153]
Pages: 18
DOI: 10.2174/1389557513666140103102447