Development of Thiadiazole as an Antidiabetic Agent- A Review
Prasanna A. Datar and Tejashree A. Deokule
Affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune-400041, India.
Keywords: Antidiabetic, cannabinoid-1 receptor, c-Jun N-terminal kinase, dipeptidyl peptidase-4, peroxisome proliferatoractivated
receptor, protein tyrosine phosphatase, sodium-glucose linked transporter, thiadiazole.
This review provides a brief summary of thiadiazole ring containing compounds as antidiabetic agents. It
covers the most active thiadiazole derivatives selected from reported literature of thiadiazole system as antidiabetic drug
substance in the form of synthesis and structural activity relationship study reports. Some of the promising thiadiazole
compounds interacting with targets such as sodium-glucose linked transporter, peroxisome proliferator-activated receptor,
protein tyrosine phosphatase, c-Jun N-terminal kinase, dipeptidyl peptidase-4 and cannabinoid-1 receptor have been
collected with their biological potency. The information provided in this review acts as important overview for medicinal
chemist to develop a new chemical entity possessing antidiabetic activity.
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