Overactive bladder is a common disorder that affects over 100 million adults worldwide though its prevalence
has been grossly underestimated. The magnitude of this problem is increasing steadily with the growing elderly
population, increased incidence of obesity, polypharmacy and increased awareness, making its treatment a challenging
task for the physician.
The treatment strategies may be nonpharmacologic or pharmacologic or both. Physical therapy techniques, such as
bladder training, pelvic-floor exercises and electrical stimulation of the pelvic floor - are the nonpharmacological therapies
that mitigate the sufferings of such patients.
Anticholinergic agents remain the mainstay of the pharmacological therapy and act by decreasing or inhibiting the
intensity of involuntary detrusor contractions. Immediate-release oxybutynin was the first dedicated antimuscarinic agent
used for the treatment of overactive bladder symptoms. With geographic differences, other currently approved
antimuscarinics are propiverine, tolterodine (immediate and extended release), trospium chloride (immediate and extended
release), solifenacin (extended release), darifenacin (extended release) and fesoterodine(extended release). Still in the
research phase and for use in refractory OAB are gabapentine and intradetrusor injection of botulinum toxin A.
Symptom relief has been observed by more direct neuromodulatory techniques, such as acupuncture, posterior tibial nerve
stimulation and sacral nerve stimulation, that address the underlying neurologic condition, although urodynamic data have
not corroborated the same. Surgical intervention such as bladder augmentation, may rarely be resorted to in those with
refractory urge incontinence and failure of conservative treatments.
Eventually, the aim of all the treatment modalities is to improve the patients’ quality of life.