Platinum(II) and Palladium(II) Complex Compounds as Anti-cancer Drugs. Methods of Cytotoxicity Determination
The studies of new anti-cancer drugs are constantly in the centre of scientific interest. This paper provides an
overview of the complex compounds of platinum(II) and palladium(II) as anti-cancer drugs. These drugs have been described
in dependence on the type of cells which are under the influence of the cytotoxic drug and side effects arising
from the use of the drug. In the case of some drugs such as cisplatin or trans-[PtCl2(tz)2] the mechanisms of action in the
body are described. Furthermore, in the paper the methods used for cytotoxicity determination of chemical compounds
considered to be used as anticancer drugs are described. The MTT, MTS, LDH, BrdU, Alamar Blue and Neutral Red test
are examples of such methods.
Keywords: Cisplatin, cytotoxicity, platinum(II) and palladium(II) complexes.
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