Protective Effect of CCR5 Delta-32 Allele Against HIV-1 in Mexican Women
JesUs A. Estrada-Aguirre, Silvestre G. Cazarez-Salazar, Luis A. Ochoa-Ramirez, Selene de J. Acosta-Cota, Roman Zamora-Gomez, Guilermi M. Najar-Reyes, Perla Villarreal-Escamilla, Ignacio Osuna-Ramirez, Sylvia P. Diaz-Camacho, Jorge G. Sanchez-Zazueta, Juan J. Rios-Tostado and Jesus S. Velarde-Felix
Pages 506-510 (5)
C-C chemokine receptor type 5 (CCR5) is known for its role as a co-receptor for HIV-1 infection. Some
individuals possess a 32 bp deletion, known as Delta-32 allele which has been reported to confer resistance to HIV-1
infection. In order to estimate the distribution of Delta-32 allele of CCR5 gene, 1034 mestizo individuals from the
Northwest of Mexico, including 385 HIV-1-infected individuals, 472 healthy controls and 177 uninfected female sex
workers; were examined by allele-specific PCR. There was no statistically significant difference in the frequency of
Delta-32 allele between HIV-1 positive and healthy individuals (OR= 1.1, p= 0.6). However, we found a significantly
reduced prevalence of CCR5 Delta-32 heterozygous genotype in female patients (OR= 0.084, 95% CI= 0.011 - 0.630, p=
0.002), as well as in allele frequency, compared to male patients. Furthermore, we observed an inverse relationship
between allele frequency and the risk of HIV-1 transmission and AIDS progression among female healthy controls, sex
workers and HIV-1 infected groups. Our findings support previous data showing Delta-32 as a genetic protective factor
against HIV-1 infection in Mexican women, as well as in women from other populations.
AIDS, CCR5, delta-32, genetic marker, HIV-1, population genetics.
Unidad Academica Escuela de Biologia, Universidad Autonoma de Sinaloa, Culiacán, Sinaloa, Mexico. Av. De las Americas y Blvd. Universitarios s/n, Ciudad Universitaria, Culiacan, Sinaloa, Mexico.