An efficient method has been developed for the synthesis of substituted 1,5-benzoxazepines and benzothiazepines
under classical heating conditions or microwave irradiation in the presence of an efficient and reusable Potassium
Dodecatungstocobaltate Trihydrate (PDTC, K5CoW12O40.3H2O) as heterogeneous catalyst which was found to be highly
active and afforded excellent yields. The products 6,8,9 and 10 were synthesized using the starting compounds 4a-d, 1
mol% PDTC and achieved in good yields by reflux (70-80%) as well as microwave conditions (60-70%). The reactions of
17a-e with 7, in the presence of 1 mol % PDTC were refluxed in dry ethanol for 6-8 h to isolate the compounds 18a-e in
good yields (70-85%) as syrups.
Keywords: Potassium Dodecatungstocobaltate Trihydrate, 1, 5-benzoxazepines and 1, 5-benzothiazepines, solvent-free conditions,
classical heating or microwave irradiation.
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