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Letters in Organic Chemistry
ISSN (Print): 1570-1786
ISSN (Online): 1875-6255
VOLUME: 11
ISSUE: 4
DOI: 10.2174/1570178610666131230235759      Price:  $58









DHA: An Excellent Source of Bioactive Heterocycles

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Author(s): Girish Kumar Gupta, Ankit Mittal and Vinod Kumar
Pages 273-286 (14)
Abstract:
Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles, substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature survey upto 2013.
Keywords:
Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.
Affiliation:
Department of Pharmaceutical Chemistry, Maharishi Markandeshwar College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala-133207, India.