DHA: An Excellent Source of Bioactive Heterocycles
Girish Kumar Gupta,
Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of
various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to
be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles,
substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines
etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature
survey upto 2013.
Keywords: Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.
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