DHA: An Excellent Source of Bioactive Heterocycles
Girish Kumar Gupta, Ankit Mittal and Vinod Kumar
Pages 273-286 (14)
Dehydroacetic acid (DHA) and its simple derivatives find many interesting applications in the synthesis of
various heterocyclic compounds of potential biological interest. A variety of DHA based chemical reactions were found to
be useful in the synthesis of 3-cinnamoyl-4-hydroxy-6-methyl-2-oxo-2H-pyrans i.e. Chalcone analogues of DHA, pyranopyrazoles,
substituted pyrones, 2H-Pyran and 2H-pyridine-2-ones, pyrimidines, pyrazoles, thiazoles, and pyridazines
etc. The present review focuses on the synthetic and biological potential of DHA and provides update on the literature
survey upto 2013.
Biological activity, Dehydroacetic acid, Heterocycle, Synthetic method.
Department of Pharmaceutical Chemistry, Maharishi Markandeshwar College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala-133207, India.