Synthesis and Antioxidant Activity of Novel Quinazolinones Functionalized with Urea/Thiourea/Thiazole Derivatives as 5-Lipoxygenase Inhibitors
Maralekere K. Prashanth and Hosakere D. Revanasiddappa
Affiliation: Department of Chemistry, University of Mysore, Manasagangothri Mysore-570006, Karnataka, India.
In the present study, a series of novel quinazolinones functionalized with urea/thiourea/thiazole derivatives was
synthesized and evaluated for their antioxidant and 5-lipoxygenase (5-LOX) inhibition activities. The newly synthesized
compounds were characterized using 1H NMR, 13C NMR, IR, Mass spectra and elemental analysis. The antioxidant activities
of the title compounds were evaluated using DPPH, superoxide, hydroxyl and nitric oxide radical scavenging assay
in vitro. It is revealed from the antioxidant screening results that the compounds 3e, 5f and 6c manifested profound
antioxidant potential. The synthesized compounds were screened for their 5-LOX inhibitory activity. Overall, 3e, 5f and
6c showed promising antioxidant and 5f showed 5-LOX inhibitory activity and may be used as the lead compounds in the
Keywords: Quinazolinone, Thiazole, Thiourea, Antioxidant, 5-LOX.
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