Current Tissue Engineering

Herman S. Cheung  
Department of Biomedical Engineering
University of Miami
Miami, FL 33101
USA

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Islet Purification for Clinical Islet Transplantation

Author(s): Hirofumi Noguchi

Affiliation: Department of Surgery, Chiba-East National Hospital, National Hospital Organization, 673 Nitonacho, Chuo-ku, Chiba 260-8712, Japan.

Keywords: Density, islet isolation, islet transplantation, osmolality, regular purification, supplemental purification.

Abstract:

In clinical islet transplantation, islet purification reduces the amount of tissues to be transplanted by removing the acinar tissue, therefore minimizing the risks associated with intraportal infusion. On the other hand, the purification procedure may result in decreased numbers of islets recovered from digested tissue and may be traumatic for the islets. Ficoll- based density gradients are widely used in islet purification in clinical trials. Recently, purification with iodixanol was reported in an islet transplantation series with successful clinical outcomes. This review describes current advances in islet purification for clinical islet transplantation.

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Article Details

VOLUME: 3
ISSUE: 1
Page: [34 - 38]
Pages: 5
DOI: 10.2174/2211542002666131230234825