Current Tissue Engineering

Herman S. Cheung  
Department of Biomedical Engineering
University of Miami
Miami, FL 33101


Islet Purification for Clinical Islet Transplantation

Author(s): Hirofumi Noguchi.


In clinical islet transplantation, islet purification reduces the amount of tissues to be transplanted by removing the acinar tissue, therefore minimizing the risks associated with intraportal infusion. On the other hand, the purification procedure may result in decreased numbers of islets recovered from digested tissue and may be traumatic for the islets. Ficoll- based density gradients are widely used in islet purification in clinical trials. Recently, purification with iodixanol was reported in an islet transplantation series with successful clinical outcomes. This review describes current advances in islet purification for clinical islet transplantation.

Keywords: Density, islet isolation, islet transplantation, osmolality, regular purification, supplemental purification.

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Article Details

Year: 2014
Page: [34 - 38]
Pages: 5
DOI: 10.2174/2211542002666131230234825