Essential Structural Features of Novel Antischizophrenic Drugs: A Review
William Bret Church.
Due to the wide range of chemical structures and variety of mechanisms of action of antischizophrenic agents,
it is difficult to identify and confirm a common pharmacophore. The present review summarizes various pharmacophore
models for antischizophrenic activity including those based on the new targets, the kynurenine aminotransferase (KATs),
which may facilitate the development of novel drugs. Some models illustrate the structural differences of compounds with
mechanisms of action considered similar, and yet others demonstrate pharmacophore models for similar chemical classes
of compounds for which the mechanism of antischizophrenic action is still not clear. In this study, we discuss the pharmacophore
models for antipsychotics including phenothiazine, butyrophenone, thioxanthene, and atypical agents along with
the novel antischizophrenic agents which are inhibitors of KATs isozymes.
Keywords: Antipsychotic, antischizophrenic, dopamine D2, pharmacophore, KATs inhibitors, serotonin 5-HT2A.
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