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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)
ISSN (Print): 1871-5230
ISSN (Online): 1875-614X
Epub Full Text Article
DOI: 10.2174/1871523012666131229132519      Price:  $95









A Novel Method Aimed at Counteracting the Side Effects Caused by Prostaglandin E2 Deficiency during Non-Steroidal Anti-Inflammatory Drug Therapy

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Author(s): Serghei Gargaun and Liubov Gargaun
Abstract:
Background: Prostaglandin E2 (PGE2) plays key physiological roles within the body’s organs and the systemic environment. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the biosynthesis of PGE2, which can lead to global PGE2 deficiency, resulting in serious side effects in the gastrointestinal, renal and other systems. In contrast, various pyridine derivatives have been found to increase endogenous PGE2 levels within multiple organs and the systemic environment. We hypothesised that the use of pyridine derivatives (nicotinic acid, nicotinyl alcohol, pyridinol carbamate, pyridoxine hydrochloride and pyridostigmine bromide) can recover PGE2 levels during NSAID treatment. Methods: Reassessment of experimental data on PGE2 levels in NSAIDs and pyridine derivatives treatment, and in controls from four previously published, independent studies. Results: Overall, in all our investigations P values for unpaired or pair-wise comparisons were not statistically significant. This finding is based on both in vitro studies using animal and human tissues and in vivo studies performed with healthy volunteers. Conclusions: We demonstrated that using pyridine derivatives along with NSAIDs, such as nonselective cyclooxygenase (COX) and selective COX-2 inhibitors, does not reduce endogenous PGE2 expression to below basal levels. Using pyridine derivatives to correct a PGE2 deficiency during NSAID treatment is a novel method that we propose can offer a valuable, cost-effective therapeutic approach to preventing and treating the side effects of NSAIDs
Keywords:
Anti-Inflammatory Agents, Drug Development, Drug Interactions, Drug Side Effects, Non-Steroidal Anti- Inflammatory Drugs, Prostaglandin E2, Pyridine Derivatives
Affiliation:
Medical Development Director, Selag Inc. 203-105 La Rose Ave Toronto, Ontario, M9P 1A9 Canada