Euthyroid Depression: The Role of Thyroid Hormone
Sanjay Kalra and Yatan Pal Singh Balhara
Affiliation: National Drug Dependence Treatment Centre (NDDTC), WHO Collaborating Centre on Substance Abuse, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Keywords: Antidepressant, depression, endocrinology, psychiatry, thyroid, thyroxine.
Thyroid dysfunction and psychiatric disorders share a bidirectional relation. Thyroid hormones have been
found to affect the central nervous system both structurally and functionally. Conventional antidepressant drug therapy is
characterized by a delayed and at times suboptimal response. Various strategies have been devised in order to circumvent
this limitation. L- Thyroxine has been used as both acceleration therapy and augmentation therapy as adjuvant therapy
with antidepressants. The hormone has also been used as monotherapy, both in prevention and management of depression.
The potential use of thyroid hormone as an adjunct therapy in management of euthyroid depression and relevant patents
has been discussed.
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