Current Drug Discovery Technologies

  • Vladimir P. Torchilin  
    Department of Pharmaceutical Science Center
    for Pharmaceutical Biotechnology and Nanomedicine
    Northeastern University
    Boston, MA 02115


Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology

Author(s): Mukesh Chandra Joshi, Krishan Kumar and Vikrant Kumar

Affiliation: Department of Chemistry, Motilal Nehru College, University of Delhi, Delhi-110021, India.

Keywords: Clinical trial, glioblastoma cell lines, leukemia and lymphoma cell lines, phosphoinositide 3-kinase, proliferation, tumor inhibitors.


The Phosphoinositide 3-kinase (PI3k) is an important regulator of intracellular signalling pathways, like cell proliferation, migration, survival, and angiogenesis upon activation by growth factor or receptors. The PI3k’s pathway is frequently up-regulated in human cancers, thus inhibition of PI3k’s is a promising approach for cancer therapy. Many potent PI3k’s inhibitors have been reported so far and few of them are in clinical trial like GDC-0941, BGT-226, AZD-6482 and others are natural products etc.

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Article Details

Page: [113 - 126]
Pages: 14
DOI: 10.2174/1570163810666131229130207