Tuberculosis: Challenges to Improve the Treatment
Mariana Moreira Lima, Ariane Trindade, Flávia Carnavalli, Aylime Castanho Bolognesi Melchior, Chung Man Chin and Jean Leandro dos Santos
Affiliation: State University of São Paulo “Júlio de Mesquita Filho” –UNESP, School of Pharmaceutical Science, Drugs and Medicines Departament, Center of Pharmaceutical Care (NAF), Rodovia Araraquara Jaú Km, 01, 14801-902 Araraquara, SP, Brazil.
Tuberculosis is one of the leading causes of morbidity and mortality worldwide. Current
treatment has several challenges, such as multi-drug resistance, extensively drug-resistance and
HIV co-infection. Problems related to patients, treatment and health care system also contribute
negatively to this panel. This review summarizes the main obstacles causing in the treatment of
tuberculosis and discusses several strategies to improve the treatment.
Keywords: Drug interactions, extensively drug-resistance, HIV, multi-drug resistance, treatment
improvement, tuberculosis, tuberculosis treatment.
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