Current Clinical Pharmacology

Arduino A. Mangoni
Flinders University and Flinders Medical Centre
Adelaide, SA


Tuberculosis: Challenges to Improve the Treatment

Author(s): Mariana Moreira Lima, Ariane Trindade, Flávia Carnavalli, Aylime Castanho Bolognesi Melchior, Chung Man Chin and Jean Leandro dos Santos

Affiliation: State University of São Paulo “Júlio de Mesquita Filho” –UNESP, School of Pharmaceutical Science, Drugs and Medicines Departament, Center of Pharmaceutical Care (NAF), Rodovia Araraquara Jaú Km, 01, 14801-902 Araraquara, SP, Brazil.


Tuberculosis is one of the leading causes of morbidity and mortality worldwide. Current treatment has several challenges, such as multi-drug resistance, extensively drug-resistance and HIV co-infection. Problems related to patients, treatment and health care system also contribute negatively to this panel. This review summarizes the main obstacles causing in the treatment of tuberculosis and discusses several strategies to improve the treatment.

Keywords: Drug interactions, extensively drug-resistance, HIV, multi-drug resistance, treatment improvement, tuberculosis, tuberculosis treatment.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [242 - 251]
Pages: 10
DOI: 10.2174/1574884708666131229124215
Price: $58