Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain

Author(s): Y. Terasaki, Y. Liu, K. Hayakawa, L.D. Pham, E.H. Lo, X. Ji, K. Arai.

Journal Name:Current Medicinal Chemistry

Volume 21 , Issue 18 , 2014

Abstract:

The neurovascular unit is now well accepted as a conceptual framework for investigating the mechanisms of ischemic stroke. From a molecular and cellular perspective, three broad mechanisms may underlie stroke pathophysiology – excitotoxicity, oxidative stress and inflammation. To date, however, most investigations of these basic mechanisms have focused on neuronal responses. In this mini-review, we ask whether these mechanisms of excitotoxicity, oxidative stress and inflammation can also be examined in terms of non-neuronal interactions in the neurovascular unit, including the release of extracellular vesicles for cell-cell signaling.

Keywords: Cell-cell interaction, extracellular vesicles, neuronal cell death, neuroprotection, neurovascular unit, stroke.

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Article Details

VOLUME: 21
ISSUE: 18
Year: 2014
Page: [2035 - 2042]
Pages: 8
DOI: 10.2174/0929867321666131228223400
Price: $58