CD147: A Novel Modulator of Inflammatory and Immune Disorders
X. Zhu, Z. Song, S. Zhang, A. Nanda and G. Li
Affiliation: Vascular Biology & Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
CD147, a transmembrane glycoprotein, is expressed on all leukocytes, platelets, and endothelial cells. It has
been implicated in a variety of physiological and pathological activities through interacting with multiple partners, including
cyclophilins, monocarboxylate transporters, Caveolin-1, and integrins. While CD147 is best known as a potent inducer
of extracellular matrix metalloproteinases (hence also called EMMPRIN), it can also function as a key mediator of inflammatory
and immune responses. Increased expression of CD147 has been implicated in the pathogenesis of a number
of diseases, such as asthma-mediated lung inflammation, rheumatoid arthritis, multiple sclerosis, myocardial infarction
and ischemic stroke. Therapeutic targeting of CD147 has yielded encouraging effects in a number of experimental models
of human diseases, suggesting CD147 as an attractive target for treatment of inflammation-related diseases. Here we review
the current understanding of CD147 expression and functions in inflammatory and immune responses and potential
implications for treatment of inflammatory disorders.
Keywords: CD147, MMP, cyclophilin, MCT, integrin, inflammation, leukocyte, platelet.
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