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Current Pharmaceutical Biotechnology
ISSN (Print): 1389-2010
ISSN (Online): 1873-4316
VOLUME: 14
ISSUE: 11
DOI: 10.2174/1389201014666131226144824      Price:  $58









Vaccination Approaches for the Prevention of Urinary Tract Infection

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Author(s): Danilo G. Moriel and Mark A. Schembri
Pages 967-974 (8)
Abstract:
Urinary tract infections (UTIs) are one of the most common infectious diseases of humans, with approximately 150 million cases estimated to occur globally every year. UTIs usually start as a bladder infection (cystitis), but can develop into acute kidney infection (pyelonephritis) and even infection of the bloodstream (urosepsis). The high frequency of UTIs in community and nosocomial settings places an enormous burden on healthcare systems worldwide. Multiple different pathogens cause UTI, with uropathogenic E. coli (UPEC) the most common etiological agent. UTIs caused by these pathogens are increasingly associated with antibiotic resistance, thus severely reducing treatment options and significantly increasing UTI-associated morbidity and mortality. In this review we present an overview of the recent advances in vaccine research targeted towards the prevention of UPEC-mediated UTI. In the context of multidrug resistance, we conclude that vaccination represents a viable approach for the prevention of chronic and recurrent UTI.
Keywords:
Escherichia coli, Urinary tract infection, Vaccine.
Affiliation:
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, QLD 4072, Brisbane, Australia.