Vaccination Approaches for the Prevention of Urinary Tract Infection
Danilo G. Moriel and Mark A. Schembri
Affiliation: Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, QLD 4072, Brisbane, Australia.
Urinary tract infections (UTIs) are one of the most common infectious diseases of humans, with approximately
150 million cases estimated to occur globally every year. UTIs usually start as a bladder infection (cystitis), but can develop
into acute kidney infection (pyelonephritis) and even infection of the bloodstream (urosepsis). The high frequency
of UTIs in community and nosocomial settings places an enormous burden on healthcare systems worldwide. Multiple
different pathogens cause UTI, with uropathogenic E. coli (UPEC) the most common etiological agent. UTIs caused by
these pathogens are increasingly associated with antibiotic resistance, thus severely reducing treatment options and significantly
increasing UTI-associated morbidity and mortality. In this review we present an overview of the recent advances
in vaccine research targeted towards the prevention of UPEC-mediated UTI. In the context of multidrug resistance,
we conclude that vaccination represents a viable approach for the prevention of chronic and recurrent UTI.
Keywords: Escherichia coli, Urinary tract infection, Vaccine.
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