In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new
compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and trans-stilbene, chalcone, and
other lipophilic groups were synthesized. They were evaluated for PPARα transactivation activity; all branched derivatives
showed an increase of the transcriptional activity of receptor compared to the linear ones. Noteworthy, stilbene
and benzophenone branched derivatives activated the PPARα better than clofibric acid.
Keywords: PPARs, clofibrate, chalcone, stilbene, transactivation assay.
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