Vanadium-Substituted Wells-Dawson Potassium Salt as Catalyst for Liquid phase Oxidation of 1,4-dihydropyridine Derivative
Laura M. Sanchez, Angel G. Sathicq, Graciela T. Baronetti and Horacio J. Thomas
Affiliation: Centro de Investigación y Desarrollo en Ciencias Aplicadas “Dr. J.J. Ronco” (CINDECA), Departamento de Química, Facultad de Ciencias Exactas, UNLP-CCT-Conicet. Calles 47 Nº 257, B1900AJK La Plata, Argentina.
Keywords: Heteropolycompound, Oxidation, Hydrogen peroxide. 1, 4-dihydropyridine.
Dawson-type heteropolyoxometalate compounds (HPC) P2M18O62
-6 (M= Mo, W) have received increasing attention
in the catalytic field due to the combination of redox and acidic properties in the same structure. It has been proved
that the introduction of vanadium into the Keggin framework is beneficial for redox catalysis, shifting its activity from
acid to redox-dominated.
In this work we prepared and characterized vanadium (V) substituted Wells-Dawson heteropolysalt (WDKV). Fresh solid
samples were characterized by 31P MAS-NMR, FTIR, SEM, XRD, TGA and Potentiometric titration measurements.
Also, we performed the oxidation of a 1,4-dihydropyridine using WDKV as catalyst in acetonitrile media, with H2O2 as
oxidant agent. The optimal procedure is the following: 1 mmol% of WDKV, a ratio 1,4-DHP: H2O2 (1:214) at reflux of
acetonitrile. It must be noted that along all reactions, no secondary products were observed.
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