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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)
ISSN (Print): 1871-5230
ISSN (Online): 1875-614X
Epub Full Text Article
DOI: 10.2174/1871523012666131224110834      Price:  $95

Synthesis of Some New Flurbiprofen Analogues as Anti-Inflammatory Agents

Author(s): Laxmikant H. Nitlikar, Jaiprakash N Sangshetti and Devanand B. Shinde
A series of new α-aryl propionic acid derivatives has been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good anti-inflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents
Azoles, α-Aryl propionic acid, Non-steroidal anti-inflammatory drugs, Rat paw edema, Suzuki cross-coupling reaction
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