Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents
Laxmikant H. Nitlikar,
Jaiprakash N. Sangshetti,
Devanand B. Shinde.
A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from
the readily available 2-fluoronitrobenzene as key starter.
The synthesized compounds were screened for their antiinflammatory
activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory
activity. The present series with some modification may serve as important core for the development of new
Keywords: Azoles, α-Aryl propionic acid, non-steroidal anti-inflammatory drugs, rat paw edema, suzuki cross-coupling reaction.
Rights & PermissionsPrintExport